• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
PublishGo to App
    Quantisnow Logo

    © 2026 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI superconnector for talent & startupsNEWLLM Arena
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13G/A filed by Prelude Therapeutics Incorporated (Amendment)

    2/12/24 4:26:50 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $PRLD alert in real time by email
    SC 13G/A 1 d749523dsc13ga.htm SC 13G/A SC 13G/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    Schedule 13G/A

    Under the Securities Exchange Act of 1934

    (Amendment No. 3)*

     

     

    Prelude Therapeutics Incorporated

    (Name of Issuer)

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

    74065P101

    (CUSIP Number)

    December 31, 2023

    (Date of Event Which Requires Filing of this Statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

    ☐ Rule 13d-1(b)

    ☐ Rule 13d-1(c)

    ☒ Rule 13d-1(d)

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

    (Continued on following pages)

     

     

     


    CUSIP #74065P101   Schedule 13G   Page 2 of 5

     

     1   

     NAME OF REPORTING PERSONS

     

     Krishna Vaddi

     2  

     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     (a) ☐  (b) ☐

     

     3  

     SEC USE ONLY

     

     4  

     CITIZENSHIP OR PLACE OF ORGANIZATION

     

     United States

    NUMBER OF

    SHARES  BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       5   

     SOLE VOTING POWER

     

     4,908,086(1)

       6  

     SHARED VOTING POWER

     

     0

       7  

     SOLE DISPOSITIVE POWER

     

     4,908,086(1)

       8  

     SHARED DISPOSITIVE POWER

     

     0

     9   

     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

     4,908,086(1)

    10  

     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     ☐

    11  

     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

     11.1%(2)

    12  

     TYPE OF REPORTING PERSON

     

     IN

     

    (1)

    Consists of (i) 3,260,216 shares of voting common stock held by the Reporting Person, of which (a) 27,008 shares are unvested as of December 31, 2023, and subject to forfeiture to the Issuer if the Reporting Person ceases to provide service to the Issuer prior to the vesting of the shares and (b) 2,192,941 shares of voting common stock are subject to options that are exercisable within 60 days of December 31, 2023, (ii) 120,665 shares of voting common stock held by Sidus Ventures, LLC, (iii) 423,655 shares of voting common stock held by Dolphin City Trust, (iv) 551,776 shares of voting common stock held by Blue Sky Trust and (v) 551,774 shares of voting common stock held by Brocade Trust. The Reporting Person is the manager of Sidus Ventures, LLC and may be deemed to have beneficial ownership over the securities held by Sidus Ventures, LLC. The Reporting Person is the beneficiary of Dolphin City Trust and may be deemed to have beneficial ownership over the securities held by Dolphin City Trust. The Reporting Person is the investment advisor for each of the Blue Sky Trust and the Brocade Trust, and may be deemed to have beneficial ownership over the securities held by each of the Blue Sky Trust and the Brocade Trust.

    (2)

    The percentage reported in row 11 is calculated in accordance with Rule 13d-3 based on the aggregate number of shares of common stock beneficial owned by the Reporting Person and an aggregate of 42,063,995 shares of common stock entitled to vote outstanding as of December 31, 2023, as reported by the Issuer to the Reporting Person, plus the number of shares of stock options held by the Reporting Person that are exercisable within 60 days of December 31, 2023, which are treated as converted into common stock only for the purpose of computing the percentage ownership of the Reporting Person.


    CUSIP #74065P101   Schedule 13G   Page 3 of 5

     

    SCHEDULE 13G

    CUSIP #74065P101

    ITEM 1(A).

    NAME OF ISSUER:

    Prelude Therapeutics Incorporated (the “Issuer”)

     

    ITEM 1(B).

    ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES:

    175 Innovation Boulevard

    Wilmington, Delaware 19805

     

    ITEM 2(A).

    NAME OF PERSONS FILING

    Krishna Vaddi (the “Reporting Person”)

     

    ITEM 2(B).

    ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:

    The address of the principal business office of the Reporting Person is:

    c/o Prelude Therapeutics Incorporated

    175 Innovation Boulevard

    Wilmington, Delaware 19805

     

    ITEM 2(C).

    CITIZENSHIP:

    United States

     

    ITEM 2(D).

    TITLE OF CLASS OF SECURITIES:

    Common Stock, par value $0.0001 per share

     

    ITEM 2(E)

    CUSIP NUMBER:

    74065P101

     

    ITEM 3.

    IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(B), OR 13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

     

    (a)

    ☐ Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o);

     

    (b)

    ☐ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

     

    (c)

    ☐ Insurance company as defined in section 3(a)19) of the Act (15 U.S.C. 78c);

     

    (d)

    ☐ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

     

    (e)

    ☐ An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

     

    (f)

    ☐ An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

     

    (g)

    ☐ A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

     

    (h)

    ☐ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

     

    (i)

    ☐ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

     

    (j)

    ☐ A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J);

     

    (k)

    ☐ Group, in accordance with §240.13d–1(b)(1)(ii)(K).


    CUSIP #74065P101   Schedule 13G   Page 4 of 5

     

    If filing as a non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J), please specify the type of institution:________________________________.

    Not applicable.

     

    ITEM 4.

    OWNERSHIP:

    (a) Amount beneficially owned:

    See Row 9 of cover page for each Reporting Person.

    (b) Percent of Class:

    See Row 11 of cover page for each Reporting Person.

    (c) Number of shares as to which such person has:

    (i) Sole power to vote or to direct the vote:

    See Row 5 of cover page for each Reporting Person.

    (ii) Shared power to vote or to direct the vote:

    See Row 6 of cover page for each Reporting Person.

    (iii) Sole power to dispose or to direct the disposition of:

    See Row 7 of cover page for each Reporting Person.

    (iv) Shared power to dispose or to direct the disposition of:

    See Row 8 of cover page for each Reporting Person.

     

    ITEM 5.

    OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

    Not applicable.

     

    ITEM 6.

    OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

    Not applicable.

     

    ITEM 7.

    IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:

    Not applicable.

     

    ITEM 8.

    IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:

    Not applicable.

     

    ITEM 9.

    NOTICE OF DISSOLUTION OF GROUP:

    Not applicable.

     

    ITEM 10.

    CERTIFICATION:

    Not applicable.


    CUSIP #74065P101   Schedule 13G   Page 5 of 5

     

    SIGNATURES

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    Date: February 12, 2024

     

    By:  

    /s/ Krishna Vaddi

      Krishna Vaddi
    Get the next $PRLD alert in real time by email

    Crush Q1 2026 with the Best AI Superconnector

    Stay ahead of the competition with Standout.work - your AI-powered talent-to-startup matching platform.

    AI-Powered Inbox
    Context-aware email replies
    Strategic Decision Support
    Get Started with Standout.work

    Recent Analyst Ratings for
    $PRLD

    DatePrice TargetRatingAnalyst
    5/4/2026$9.00Buy
    D. Boral Capital
    9/19/2024$5.00Neutral → Buy
    H.C. Wainwright
    6/20/2024$3.00Equal Weight → Underweight
    Barclays
    3/13/2024$7.00Mkt Outperform
    JMP Securities
    2/20/2024$5.00Buy → Neutral
    H.C. Wainwright
    12/19/2023$10.00 → $4.00Equal-Weight → Underweight
    Morgan Stanley
    11/21/2022$8.00 → $6.00Neutral → Underperform
    BofA Securities
    9/9/2022$19.00 → $11.00Overweight → Equal-Weight
    Morgan Stanley
    More analyst ratings

    $PRLD
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    View All

    SEC Form 4 filed by Chief Medical Officer Morris Charles Q

    4 - Prelude Therapeutics Inc (0001678660) (Issuer)

    5/4/26 4:10:00 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Large owner Ra Capital Management, L.P. disposed of 1,407,000 shares (SEC Form 4)

    4 - Prelude Therapeutics Inc (0001678660) (Issuer)

    4/28/26 5:14:55 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    New insider Ra Capital Management, L.P. claimed ownership of 7,882,882 shares (SEC Form 3)

    3 - Prelude Therapeutics Inc (0001678660) (Issuer)

    4/28/26 5:13:28 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    View All

    Director Bonita David P bought $12,499,999 worth of shares (2,815,315 units at $4.44) (SEC Form 4)

    4 - Prelude Therapeutics Inc (0001678660) (Issuer)

    4/23/26 6:50:38 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Director Orbimed Advisors Llc bought $12,499,999 worth of shares (2,815,315 units at $4.44) (SEC Form 4)

    4 - Prelude Therapeutics Inc (0001678660) (Issuer)

    4/23/26 6:48:25 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Chief Chemistry Officer Combs Andrew bought $69,250 worth of shares (100,000 units at $0.69), increasing direct ownership by 26% to 480,123 units (SEC Form 4)

    4 - Prelude Therapeutics Inc (0001678660) (Issuer)

    3/27/25 4:40:54 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Press Releases

    Fastest customizable press release news feed in the world

    View All

    Prelude Therapeutics Reports First Quarter 2026 Financial Results and Provides Corporate Update

    Initiated enrollment of Phase 1 Study of PRT12396, mutant-selective JAK2V617F inhibitor in patients with polycythemia vera (PV) and myelofibrosis (MF) The Company expects to file the IND for PRT13722, first-in-class highly-selective oral KAT6A degrader, by mid-2026 with Phase 1 study initiation in ER+ breast cancer anticipated in the 2H 2026 Presented preclinical data demonstrating differentiated profile of PRT13722, at the American Association for Cancer Research (AACR) Annual Meeting 2026 Appointed Charles Morris, M.D. as Chief Medical Officer Current cash runway expected into second quarter of 2028 based on preliminary estimates, driven by previously announced underwritten offering

    5/12/26 7:01:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Announces Pricing of $90.0 Million Underwritten Offering

    WILMINGTON, Del., April 20, 2026 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (NASDAQ:PRLD) ("Prelude" or the "Company"), a clinical-stage precision oncology company, today announced the pricing of its underwritten offering of 18,018,014 shares of its voting common stock (the "Common Stock") at a price of $4.44 per share, and, in lieu of Common Stock to investors who so chose, pre-funded warrants to purchase up to 2,252,252 shares of its Common Stock at a price of $4.4399 per pre-funded warrant, which represents the per share offering price for the Common Stock less the $0.0001 per share exercise price for each such pre-funded warrant. Before deducting the underwriting discounts a

    4/20/26 6:30:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Presents Preclinical Data from Development Candidate, PRT13722, a First-in-Class, Orally Bioavailable, Potent and Highly Selective KAT6A Degrader at American Association for Cancer Research (AACR) Annual Meeting 2026

    Data Demonstrate Potential for Differentiated Efficacy and Safety Profile, Including Complete Responses as Monotherapy in Multiple CDX and PDX Models of HR+/HER2- Breast Cancer  Prelude Remains on Track to File Investigational New Drug (IND) Application by mid-2026 and to initiate clinical trial in 2H 2026 WILMINGTON, Del., April 20, 2026 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (NASDAQ:PRLD), a precision oncology company, today announced the presentation of new preclinical data from its lead development candidate, PRT13722. PRT13722 is being developed for the treatment of hormone receptor positive (HR+)/human epidermal growth factor receptor 2 (HER2-) breast cancer (BC). Ba

    4/20/26 6:00:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    View All

    D. Boral Capital initiated coverage on Prelude Therapeutics with a new price target

    D. Boral Capital initiated coverage of Prelude Therapeutics with a rating of Buy and set a new price target of $9.00

    5/4/26 8:50:21 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics upgraded by H.C. Wainwright with a new price target

    H.C. Wainwright upgraded Prelude Therapeutics from Neutral to Buy and set a new price target of $5.00

    9/19/24 7:51:24 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics downgraded by Barclays with a new price target

    Barclays downgraded Prelude Therapeutics from Equal Weight to Underweight and set a new price target of $3.00

    6/20/24 7:37:20 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    SEC Filings

    View All

    SEC Form 10-Q filed by Prelude Therapeutics Incorporated

    10-Q - Prelude Therapeutics Inc (0001678660) (Filer)

    5/12/26 7:19:01 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Incorporated filed SEC Form 8-K: Results of Operations and Financial Condition, Regulation FD Disclosure, Financial Statements and Exhibits

    8-K - Prelude Therapeutics Inc (0001678660) (Filer)

    5/12/26 7:11:58 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form DEFA14A filed by Prelude Therapeutics Incorporated

    DEFA14A - Prelude Therapeutics Inc (0001678660) (Filer)

    4/29/26 4:11:35 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Leadership Updates

    Live Leadership Updates

    View All

    Prelude Therapeutics Reports First Quarter 2026 Financial Results and Provides Corporate Update

    Initiated enrollment of Phase 1 Study of PRT12396, mutant-selective JAK2V617F inhibitor in patients with polycythemia vera (PV) and myelofibrosis (MF) The Company expects to file the IND for PRT13722, first-in-class highly-selective oral KAT6A degrader, by mid-2026 with Phase 1 study initiation in ER+ breast cancer anticipated in the 2H 2026 Presented preclinical data demonstrating differentiated profile of PRT13722, at the American Association for Cancer Research (AACR) Annual Meeting 2026 Appointed Charles Morris, M.D. as Chief Medical Officer Current cash runway expected into second quarter of 2028 based on preliminary estimates, driven by previously announced underwritten offering

    5/12/26 7:01:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Announces the Appointment of Charles Morris, M.D. as Chief Medical Officer

    WILMINGTON, Del., April 15, 2026 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (NASDAQ:PRLD) ("Prelude Therapeutics" or the "Company"), a clinical-stage precision oncology company, today announced that Dr. Charles Morris will join the Company as Chief Medical Officer effective, April 20, 2026. "We are thrilled to welcome Dr. Charles Morris to Prelude Therapeutics as Executive Vice President and Chief Medical Officer," stated Kris Vaddi, Chief Executive Officer of Prelude Therapeutics. "With our two lead programs targeting myeloproliferative neoplasms and ER+ breast cancer advancing expected to enter into clinical development in 2026, Dr. Morris's deep clinical experience, track re

    4/15/26 7:30:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Announces Appointment of Katina Dorton, J.D., MBA to its Board of Directors

    WILMINGTON, Del., Oct. 17, 2025 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (NASDAQ:PRLD), a clinical-stage precision oncology company, today announced the appointment of Katina Dorton to its Board of Directors, effective today. Ms. Dorton has more than 30 years of industry expertise and leadership in healthcare and life sciences including service on several boards of public life science companies, executive financial leadership and investment banking. "Katina brings to Prelude an abundance of experience as a strategic and financial advisor to our leadership team," stated Kris Vaddi, Ph.D., Chief Executive Officer of Prelude. "We welcome her to our board and we look forward to

    10/17/25 7:30:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Financials

    Live finance-specific insights

    View All

    Prelude Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update

    Lead candidate from mutant selective JAK2V617F JH2 inhibitor program advancing with IND filing expected in the first quarter of 2026 Lead candidate from oral KAT6A selective degrader program advancing with IND filing expected in mid-2026 Preclinical data from JAK2V617F JH2 inhibitor program and CALR-targeted degrader antibody conjugate (DAC) program were both accepted for oral presentations at the American Society of Hematology (ASH) 67th Annual Meeting in December Current cash runway into 2027 based on preliminary estimates Company to host investor conference call and webcast on Wednesday, November 12, 2025 at 8:00 AM EST WILMINGTON, Del., Nov. 12, 2025 (GLOBE NEWSWIRE) -- Prelude T

    11/12/25 7:01:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics Announces Strategic Business Update

    Prelude to prioritize development of mutant selective JAK2V617F JH2 inhibitor and KAT6A selective degrader programs Pausing further clinical development of SMARCA2 selective degrader programs JAK2V617F option agreement with Incyte, as previously announced, includes upfront payment of $35 million, a $25 million equity investment and $100 million if option is exercised Cumulative capital expected to fund planned operations into 2027 based on the Company's preliminary estimates, and potentially into the third quarter of 2028 if Incyte exercises option on JAK2 program Company to release third quarter 2025 financial results and conduct an investor conference call on November 12, 2025 WILMIN

    11/4/25 7:05:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Prelude Therapeutics' SMARCA2 Degrader PRT3789 Demonstrated Promising Initial Clinical Activity and Safety Profile in Phase 1 Trial

    -  Encouraging signs of anti-tumor activity including objective responses observed in patients with SMARCA4-mutated non-small cell lung cancer (NSCLC) and esophageal cancer in early PRT3789 monotherapy dose escalation -  At doses studied to date, PRT3789 was generally well-tolerated with no dose-limiting toxicities or study drug-related serious adverse events -  Company to host investor conference call and webcast on Friday, September 13, 2024 at 12:00 PM EST WILMINGTON, Del., Sept. 13, 2024 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (NASDAQ:PRLD), a clinical-stage precision oncology company, today announced the first interim clinical

    9/13/24 10:00:00 AM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $PRLD
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    View All

    SEC Form SC 13G/A filed by Prelude Therapeutics Incorporated (Amendment)

    SC 13G/A - Prelude Therapeutics Inc (0001678660) (Subject)

    2/13/24 1:34:34 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form SC 13G/A filed by Prelude Therapeutics Incorporated (Amendment)

    SC 13G/A - Prelude Therapeutics Inc (0001678660) (Subject)

    2/12/24 5:30:07 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form SC 13G/A filed by Prelude Therapeutics Incorporated (Amendment)

    SC 13G/A - Prelude Therapeutics Inc (0001678660) (Subject)

    2/12/24 4:26:50 PM ET
    $PRLD
    Biotechnology: Pharmaceutical Preparations
    Health Care