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    Amendment: SEC Form SCHEDULE 13G/A filed by Krystal Biotech Inc.

    5/4/26 7:10:31 AM ET
    $KRYS
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $KRYS alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    (Amendment No. 3)


    Krystal Biotech, Inc. (the "Company")

    (Name of Issuer)


    Common Stock, $0.00001 par value ("Common Stock")

    (Title of Class of Securities)



    (CUSIP Number)


    03/31/2026

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox not checked   Rule 13d-1(c)
    Checkbox checked   Rule 13d-1(d)




    schemaVersion:


    SCHEDULE 13G

    CUSIP No.


    1Names of Reporting Persons

    Krish S. Krishnan
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    3,388,283.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    3,388,283.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,388,283.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    11.5 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.


    1Names of Reporting Persons

    Suma M. Krishnan
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    3,388,283.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    3,388,283.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,388,283.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    11.5 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Krystal Biotech, Inc. (the "Company")
    (b)Address of issuer's principal executive offices:

    2100 Wharton Street, Suite 701, Pittsburgh, Pennsylvania, 15203
    Item 2. 
    (a)Name of person filing:

    The Reporting Persons, Mr. Krish S. Krishnan and his wife, Mrs. Suma M. Krishnan, each filed a Schedule 13G on April 4, 2018, which were both then amended on February 19, 2019, and February 14, 2020 (the "Individual 13Gs"). The Reporting Persons are now reporting together on this Schedule 13G/A, which is deemed to be the 3rd Amendment to the Individual 13Gs.
    (b)Address or principal business office or, if none, residence:

    c/o KRYSTAL BIOTECH, INC. 2100 WHARTON STREET SUITE 701 PITTSBURGH, PA 15203
    (c)Citizenship:

    Mr. and Mrs. Krishnan are citizens of the United States of America.
    (d)Title of class of securities:

    Common Stock, $0.00001 par value ("Common Stock")
    (e)CUSIP No.:

    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    Each of the Reporting Persons may be deemed to be the beneficial owner of an aggregate 3,388,283 shares of the Company's Common Stock as set forth in more detail in response to Item 4(c) below.
    (b)Percent of class:

    11.5% The percentage was calculated in accordance with Rule 13d-3(d)(1)(i) promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange Act") based on an aggregate total of 29,479,756 shares of Common Stock outstanding as of April 29, 2026, as reported by the Company in its Form 10-Q filed with the U.S. Securities and Exchange Commission on May 4, 2026.
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    Krish S. Krishnan: 0 shares of Common Stock Suma M. Krishnan: 0 shares of Common Stock

     (ii) Shared power to vote or to direct the vote:

    Krish S. Krishnan: 3,388,283 shares of Common Stock Suma M. Krishnan: 3,388,283 shares of Common Stock The reported securities are directly held as follows: (i) 1,475,253 shares of Common Stock directly owned by Krish S. Krishnan; (ii) 1,403,155 shares of Common Stock directly owned by Suma M. Krishnan; (iii) 90,000 shares of Common Stock that are directly owned by the SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and dispositive power with a 3rd party co-trustee. These shares of Common Stock are not beneficially owned by Mrs. Krishnan but are included to disclose the aggregate holdings of both Reporting Persons; (iv) 90,000 shares of Common Stock that are directly owned by the Krishnan Spousal Trust, an irrevocable trust established by Mr. Krishnan for the benefit of Mrs. Krishnan who serves as a co-trustee and shares voting and dispositive power with a 3rd party co-trustee. These shares of Common Stock are not beneficially owned by Mr. Krishnan but are included to disclose the aggregate holdings of both Reporting Persons; (v) 50,000 shares of Common Stock owned by the Krishnan Family Trust, a revocable trust established for the benefit of Mr. and Mrs. Krishnan who share voting and investment control of the trust; (v) 158,525 shares of Common Stock issuable upon the exercise of stock options held by Mr. Krishnan; and (vi) 121,350 shares of Common Stock issuable upon the exercise of stock options held by Mrs. Krishnan. The Reporting Persons may be deemed to share beneficial ownership of the reported securities, but the filing of this Statement shall not be construed as an admission of such beneficial ownership for purposes of Section 13(d) or 13(g) of the Exchange Act or for any other purpose.

     (iii) Sole power to dispose or to direct the disposition of:

    Krish S. Krishnan: 0 shares of Common Stock Suma M. Krishnan: 0 shares of Common Stock

     (iv) Shared power to dispose or to direct the disposition of:

    Krish S. Krishnan: 3,388,283 shares of Common Stock Suma M. Krishnan: 3,388,283 shares of Common Stock See Item 4(c)(ii) above, which is incorporated herein by reference.

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Not Applicable
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    Not Applicable

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Krish S. Krishnan
     
    Signature:/s/ Krish S. Krishnan
    Name/Title:Krish S. Krishnan/Chariman & CEO
    Date:05/04/2026
     
    Suma M. Krishnan
     
    Signature:/s/Suma M. Krishnan
    Name/Title:Suma M. Krishnan/Director, President R&D
    Date:05/04/2026
    Exhibit Information

    Exhibit 99.1 Joint Filing Agreement

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