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    Amendment: SEC Form SCHEDULE 13G/A filed by Alector Inc.

    5/14/26 4:57:27 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $ALEC alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    (Amendment No. 7)


    Alector, Inc.

    (Name of Issuer)


    Common Stock, $0.0001 par value per share

    (Title of Class of Securities)




    014442107

    (CUSIP Number)
    03/31/2026

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox not checked   Rule 13d-1(c)
    Checkbox checked   Rule 13d-1(d)




    schemaVersion:


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Polaris Venture Partners VI, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    498,468.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    498,468.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    498,468.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    0.5 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  All shares are held of record by PVP VI (as defined in Item 2(a) of the Original Schedule 13G (as defined below)). PVM VI (as defined in Item 2(a) of the Original Schedule 13G), the general partner of PVP VI, may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of the Issuer's common stock ("Common Stock") outstanding as of February 20, 2026, as set forth in the Issuer's annual report on Form 10-K for the year ended December 31, 2026, filed with the United States Securities and Exchange Commission (the "Commission") on February 25, 2026 (the "Form 10-K").


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Polaris Venture Partners Founders' Fund VI, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    267,979.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    267,979.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    267,979.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    0.2 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  All shares are held of record by PVPFF VI (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVPFF VI, may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Polaris Venture Partners VI (AIV), L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    3,280,842.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    3,280,842.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,280,842.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    3.0 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  All shares are held of record by PVP VI (AIV) (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVP VI (AIV), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Polaris Venture Partners VI (AIV-B), L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    806,528.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    806,528.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    806,528.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    0.7 %
    12Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:  All shares are held of record by PVP VI (AIV-B) (as defined in Item 2(a) of the Original Schedule 13G). PVM VI, the general partner of PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Polaris Venture Management Co VI, L.L.C.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,853,817.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.4 %
    12Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:  The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    David Barrett
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,853,817.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.4 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Brian Chee
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,853,817.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.4 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Jonathan A. Flint
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    39,124.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    39,124.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,892,941.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.4 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  The shares reported in Rows 5 and 7 are held directly by Jonathan A. Flint. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Terrance G. McGuire
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    319,682.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    319,682.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    5,173,499.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.7 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  The shares reported in Rows 5 and 7 consist of (i) 96,435 shares held directly by Terrance G. McGuire, (ii) 196,997 shares held by McGuire Family Trust, and (iii) 26,250 shares consist of restricted stock units that have been granted to Terrance G. McGuire in his capacity as a former director of the Issuer. Terrance G. McGuire is the donor of the McGuire Family Trust and may be deemed to share voting, investment and dispositive power with respect to the shares held by the McGuire Family Trust. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,388,831 shares of Common Stock, calculated as follows: (i) 26,250 shares that represent restricted stock units that have been granted to Mr. McGuire in his capacity as a former director of the Issuer plus (ii) 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Amir Nashat
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    131,332.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    131,332.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,985,149.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.5 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:  The shares reported in Rows 5 and 7 are held directly by Amir Nashat. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    CUSIP Number(s):
    014442107


    1Names of Reporting Persons

    Bryce Youngren
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    11,864.00
    6Shared Voting Power

    4,853,817.00
    7Sole Dispositive Power

    11,864.00
    8Shared Dispositive Power

    4,853,817.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,865,681.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    4.4 %
    12Type of Reporting Person (See Instructions)

    IN

    Comment for Type of Reporting Person:   The shares reported in Rows 5 and 7 are held directly by Bryce Youngren. The shares reported in Rows 6 and 8 consist of (i) 498,468 shares held of record by PVP VI, (ii) 267,979 shares held of record by PVPFF VI, (iii) 3,280,842 shares held of record by PVP VI (AIV) and (iv) 806,528 shares held of record by PVP VI (AIV-B). PVM VI, the general partner of each of PVP VI, PVPFF VI, PVP VI (AIV) and PVP VI (AIV-B), may be deemed to have voting, investment and dispositive power with respect to these securities. David Barrett, Brian Chee, Jonathan A. Flint, Terrance G. McGuire, Amir Nashat, and Bryce Youngren are the managing members of PVM VI and may each be deemed to share voting, investment and dispositive power with respect to these securities. The percentage in Row 11 is based on 110,362,581 shares of Common Stock outstanding as of February 20, 2026, as set forth in the Form 10-K.


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Alector, Inc.
    (b)Address of issuer's principal executive offices:

    131 OYSTER POINT BLVD., SUITE 600, SOUTH SAN FRANCISCO, CA, 94080
    Item 2. 
    (a)Name of person filing:

    This Amendment No. 7 (this "Amendment") amends and supplements the Schedule 13G initially filed with the Commission on February 12, 2020, as amended by Amendment No. 1 filed with the Commission on February 12, 2021, Amendment No. 2 filed with the Commission on February 11, 2022, Amendment No. 3 filed with the Commission on February 7, 2023, Amendment No. 4 filed with the Commission on February 9, 2024, Amendment No. 5 filed with the Commission on November 12, 2024, and Amendment No. 6 filed with the Commission on November 13, 2025 (collectively, the "Original Schedule 13G"). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13G remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13G. The following information in Item 4 with respect to the ownership of the Issuer's Common Stock by the Reporting Persons filing this Amendment No. 7 is provided as of April 30, 2026. Each of the Reporting Persons disclaims beneficial ownership of the shares of Common Stock reported in this Amendment No. 7, except for the shares, if any, such Reporting Person holds of record and to the extent of such Reporting Person's pecuniary interest therein.
    (b)Address or principal business office or, if none, residence:

    (c)Citizenship:

    (d)Title of class of securities:

    Common Stock, $0.0001 par value per share
    (e)CUSIP No.:

    014442107
    Item 4.Ownership
    (a)Amount beneficially owned:

    See Row 9 of cover page for each Reporting Person and the corresponding footnotes.
    (b)Percent of class:

    See Row 11 of cover page for each Reporting Person and the corresponding footnotes.
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    See Row 5 of cover page for each Reporting Person and the corresponding footnotes.

     (ii) Shared power to vote or to direct the vote:

    See Row 6 of cover page for each Reporting Person and the corresponding footnotes.

     (iii) Sole power to dispose or to direct the disposition of:

    See Row 7 of cover page for each Reporting Person and the corresponding footnotes.

     (iv) Shared power to dispose or to direct the disposition of:

    See Row 8 of cover page for each Reporting Person and the corresponding footnotes.

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Checkbox checked    Ownership of 5 percent or less of a class

    Item 10.Certifications:
     
    Not Applicable

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Polaris Venture Partners VI, L.P.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Authorized Signatory of Polaris Venture Management Co. VI, L.L.C., general partner of Polaris Venture Partners VI, L.P.
    Date:05/14/2026
     
    Polaris Venture Partners Founders' Fund VI, L.P.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Authorized Signatory of Polaris Venture Management Co. VI, L.L.C., GP of Polaris Venture Partners Founders' Fund VI, L.P.
    Date:05/14/2026
     
    Polaris Venture Partners VI (AIV), L.P.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Authorized Signatory of Polaris Venture Management Co. VI, L.L.C., general partner of Polaris Venture Partners VI (AIV), L.P.
    Date:05/14/2026
     
    Polaris Venture Partners VI (AIV-B), L.P.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Authorized Signatory of Polaris Venture Management Co. VI, L.L.C., general partner of Polaris Venture Partners VI (AIV-B), L.P.
    Date:05/14/2026
     
    Polaris Venture Management Co VI, L.L.C.
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Authorized Signatory*
    Date:05/14/2026
     
    David Barrett
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026
     
    Brian Chee
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026
     
    Jonathan A. Flint
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026
     
    Terrance G. McGuire
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026
     
    Amir Nashat
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026
     
    Bryce Youngren
     
    Signature:/s/ Lauren Crockett
    Name/Title:Lauren Crockett/ Attorney-In-Fact
    Date:05/14/2026

    Comments accompanying signature:   This Schedule 13G was executed pursuant to a Power of Attorney. Note that copies of the applicable Power of Attorney are already on file with the appropriate agencies.
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    3/10/2026$6.00Neutral → Buy
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    10/22/2025$1.50Outperform → Neutral
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    10/22/2025Buy → Hold
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    SEC Filings

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    Amendment: SEC Form SCHEDULE 13G/A filed by Alector Inc.

    SCHEDULE 13G/A - Alector, Inc. (0001653087) (Subject)

    5/14/26 4:57:27 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form 8-K filed by Alector Inc.

    8-K - Alector, Inc. (0001653087) (Filer)

    5/7/26 5:15:33 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    SEC Form 424B5 filed by Alector Inc.

    424B5 - Alector, Inc. (0001653087) (Filer)

    5/7/26 5:13:54 PM ET
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    Insider Trading

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    Director Scheller Richard H was granted 10,833 shares, increasing direct ownership by 11% to 106,199 units (SEC Form 4)

    4 - Alector, Inc. (0001653087) (Issuer)

    6/3/26 7:08:32 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Chief Executive Officer Rosenthal Arnon sold $172,191 worth of shares (87,216 units at $1.97), decreasing direct ownership by 4% to 2,367,206 units (SEC Form 4) to cover withholding tax

    4 - Alector, Inc. (0001653087) (Issuer)

    6/3/26 5:30:17 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Principal Accounting Officer Wong-Sarad Grace sold $17,813 worth of shares (9,184 units at $1.94) as part of a pre-agreed trading plan, decreasing direct ownership by 9% to 95,461 units (SEC Form 4) to satisfy tax liability

    4 - Alector, Inc. (0001653087) (Issuer)

    6/3/26 5:30:14 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    $ALEC
    Press Releases

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    Alector Reports First Quarter 2026 Financial Results and Provides Business Update

    Advancing the Alector Brain Carrier (ABC) platform across multiple therapeutic modalities, including antibodies, enzymes, and siRNA, with continued progress across AL037/AL137 (ABC-enabled antibody for Alzheimer's disease (AD)), AL050 (ABC-enabled GCase Enzyme Replacement Therapy for Parkinson's disease (PD)), and AL064/AL164 (ABC-enabled Tau siRNA for AD and other tauopathies) $206.5 million in cash, cash equivalents and investments provide runway at least through 2027 SOUTH SAN FRANCISCO, Calif., May 07, 2026 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a biotechnology company focused on developing therapies to counteract the devasting progression of neurodegeneration, today report

    5/7/26 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Alector to Discontinue Phase 2 PROGRESS-AD Trial of Nivisnebart (AL101/GSK4527226) in Early Alzheimer's Disease Following Interim Futility Analysis

    --Independent data monitoring committee (IDMC) determined the trial unlikely to meet primary endpoint –  --Alector remains focused on advancing its pipeline of novel ABC-enabled candidates, including an anti-Aβ antibody for Alzheimer's disease (AD), a GCase enzyme replacement therapy (ERT) for Parkinson's disease (PD), a tau siRNA for AD, an α-synuclein siRNA for PD, and an NLRP3 siRNA for multiple neurological and metabolic disorders, alongside several first-in-class discovery programs— SOUTH SAN FRANCISCO, Calif., April 29, 2026 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a biotechnology company focused on developing therapies to counteract the devastating progression of neurodege

    4/29/26 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

    Advancing the Alector Brain Carrier (ABC) platform across multiple therapeutic modalities, including antibodies, enzymes, and siRNA, with continued progress across AL137 (ABC-enabled anti-amyloid antibody for Alzheimer's Disease), AL050 (ABC-enabled GCase Enzyme Replacement Therapy for Parkinson's Disease) and AL064 (ABC-enabled Tau siRNA for Alzheimer's Disease) Independent interim futility analysis of the PROGRESS-AD Phase 2 trial of nivisnebart (AL101) in early Alzheimer's disease expected in the first half of 2026 $256.0 million in cash, cash equivalents and investments provide runway at least through 2027 SOUTH SAN FRANCISCO, Calif., Feb. 25, 2026 (GLOBE NEWSWIRE) -- Alector, Inc.

    2/25/26 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    $ALEC
    Analyst Ratings

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    Alector upgraded by Cantor Fitzgerald

    Cantor Fitzgerald upgraded Alector from Neutral to Overweight

    4/15/26 8:04:10 AM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector upgraded by BTIG Research with a new price target

    BTIG Research upgraded Alector from Neutral to Buy and set a new price target of $6.00

    3/10/26 8:36:07 AM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Alector downgraded by Mizuho with a new price target

    Mizuho downgraded Alector from Outperform to Neutral and set a new price target of $1.50

    10/22/25 7:10:52 AM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    $ALEC
    Leadership Updates

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    Alector Appoints Neil Berkley as Chief Financial Officer and Chief Business Officer

    SOUTH SAN FRANCISCO, Calif., Dec. 12, 2025 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a clinical-stage biotechnology company focused on developing therapies to counteract the devastating progression of neurodegeneration, today announced that Neil Berkley, who has served as Alector's Chief Business Officer (CBO) since March 2024, and CBO and Interim Chief Financial Officer (CFO) since June 2025, has been appointed CFO, effective December 10, 2025. Mr. Berkley will continue to serve as CBO. "Neil has demonstrated exceptional leadership, judgment, strategic insight, and an unwavering commitment to Alector's mission," said Arnon Rosenthal, Ph.D., Chief Executive Officer of Alector. "His

    12/12/25 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector Reports First Quarter 2024 Financial Results and Provides Business Update

    Data from INVOKE-2, evaluating the most advanced TREM2 candidate in clinical development for early Alzheimer's disease, on track for Q4 2024 Strengthened leadership team with key appointments: Neil Berkley, M.S., M.B.A., named Chief Business Officer; Errol De Souza, Ph.D., and Mark Altmeyer, M.B.A., join Board of Directors $562.1 million in cash, cash equivalents and investments provide runway through 2026 SOUTH SAN FRANCISCO, Calif., May 08, 2024 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a clinical-stage biotechnology company pioneering immuno-neurology, today reported first quarter 2024 financial results and recent portfolio and business updates. As of March 31, 202

    5/8/24 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector Announces Appointment of Gary Romano, M.D., Ph.D., as Chief Medical Officer

    SOUTH SAN FRANCISCO, Calif., March 29, 2022 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a clinical-stage biotechnology company pioneering immuno-neurology, today announced the appointment of Gary Romano, M.D., Ph.D., as Chief Medical Officer. In this role, Dr. Romano will lead the company's global clinical development strategy, including oversight of the clinical development, clinical operations, biometrics and digital science, and medical affairs functions. Dr. Romano will report to Sara Kenkare-Mitra, Ph.D., President and Head of Research and Development of Alector. Dr. Romano's appointment is effective May 23, 2022. "We are delighted to welcome Gary to our executive leadership tea

    3/29/22 4:05:00 PM ET
    $ALEC
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    $ALEC
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    Alector Reports Second Quarter 2025 Financial Results and Provides Business Update

    On track to report topline data by mid-Q4 2025 from the pivotal INFRONT-3 Phase 3 clinical trial of latozinemab in FTD-GRN, a severe, rare form of dementia with no approved treatments Ongoing Phase 2 PROGRESS-AD trial of AL101 in early Alzheimer's disease expected to complete in 2026 Continuing to progress Alector Brain Carrier programs, including the company's anti-amyloid beta antibody, engineered GCase enzyme replacement therapy, and anti-tau siRNA $307.3 million in cash, cash equivalents, and investments provides runway into the second half of 2027 Management to host conference call and webcast today at 4:30 p.m. ET/1:30 p.m. PT SOUTH SAN FRANCISCO, Calif., Aug. 07, 2025 (GLOBE NE

    8/7/25 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector to Host Second Quarter and Mid-Year 2025 Earnings Conference Call

    SOUTH SAN FRANCISCO, Calif., July 31, 2025 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a late-stage clinical biotechnology company focused on developing therapies to counteract the devastating progression of neurodegeneration, today announced it will host a conference call and webcast on Thursday, August 7, 2025, at 4:30 p.m. ET to discuss results for the second quarter ended June 30, 2025, and provide a mid-year business update. The call will feature remarks from Ryan Darby, M.D., Associate Professor of Neurology and Director of the Frontotemporal Dementia Clinic at Vanderbilt University Medical Center, who will speak on the unmet need in frontotemporal dementia. A press release deta

    7/31/25 4:05:00 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Alector Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update

    Topline data from the pivotal INFRONT-3 Phase 3 clinical trial of latozinemab in FTD-GRN expected by Q4 2025 Anticipate completing enrollment in the PROGRESS-AD Phase 2 clinical trial of AL101/GSK4527226 in participants with early Alzheimer's disease by mid-2025 Applying Alector Brain Carrier to advance therapeutic candidates, including those targeting amyloid beta and replacing GCase $413.4 million in cash, cash equivalents and investments provide runway through 2026 Management to host conference call and webcast today at 4:30 p.m. ET/1:30 p.m. PT SOUTH SAN FRANCISCO, Calif., Feb. 26, 2025 (GLOBE NEWSWIRE) -- Alector, Inc. (NASDAQ:ALEC), a late-stage clinical biotechnology company

    2/26/25 4:05:00 PM ET
    $ALEC
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    SEC Form SC 13G filed by Alector Inc.

    SC 13G - Alector, Inc. (0001653087) (Subject)

    12/6/24 5:30:28 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Amendment: SEC Form SC 13G/A filed by Alector Inc.

    SC 13G/A - Alector, Inc. (0001653087) (Subject)

    11/12/24 7:21:57 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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    Amendment: SEC Form SC 13G/A filed by Alector Inc.

    SC 13G/A - Alector, Inc. (0001653087) (Subject)

    11/7/24 12:41:31 PM ET
    $ALEC
    Biotechnology: Biological Products (No Diagnostic Substances)
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