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    SEC Form 4 filed by Director Forman Stephen J.

    7/8/25 9:33:07 PM ET
    $LIXT
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $LIXT alert in real time by email
    SEC FORM 4 SEC Form 4
    FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0287
    Estimated average burden
    hours per response: 0.5
      
    Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
      
    Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
    1. Name and Address of Reporting Person*
    Forman Stephen J.

    (Last) (First) (Middle)
    680 E. COLORADO BLVD., SUITE 180

    (Street)
    PASADENA CA 91101

    (City) (State) (Zip)
    2. Issuer Name and Ticker or Trading Symbol
    LIXTE BIOTECHNOLOGY HOLDINGS, INC. [ LIXT ]
    5. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    X Director 10% Owner
    Officer (give title below) Other (specify below)
    3. Date of Earliest Transaction (Month/Day/Year)
    06/30/2025
    4. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    X Form filed by One Reporting Person
    Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
    1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V Amount (A) or (D) Price
    Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
    Options to Purchase Common Stock $0.905 06/30/2025 A 10,000 09/30/2025 06/30/2030 Common 10,000 $0(1) 10,000 D
    Options to Purchase Common Stock $0.905 06/30/2025 A 7,754 06/30/2025 06/30/2030 Common 7,754 $0(2) 7,754 D
    Options to Purchase Common Stock $1.21 03/31/2025 03/31/2030 Common 5,851 5,851 D
    Options to Purchase Common Stock $2.33 01/20/2025 01/20/2030 Common 3,030 3,030 D
    Options to Purchase Common Stock $1.3 09/30/2024 09/30/2029 Common 3,858 3,858 D
    Options to Purchase Common Stock $2.37 06/30/2024 06/30/2029 Common 10,000 10,000 D
    Options to Purchase Common Stock $2.37 06/30/2024 06/30/2029 Common 3,018 3,018 D
    Options to Purchase Common Stock $5.88 06/30/2023 06/30/2028 Common 10,000 10,000 D
    Options to Purchase Common Stock $7.45 06/30/2022 06/30/2027 Common 10,000 10,000 D
    Options to Purchase Common Stock $30.3 06/30/2021 06/30/2026 Common 10,000 10,000 D
    Options to Purchase Common Stock $32.1 01/06/2021 01/06/2026 Common 5,000 5,000 D
    Warrants to Purchase Common Stock $57 12/07/2018 12/07/2022 Common 2,105 2,105 I By Stephen Forman Living Trust
    Options to Purchase Common Stock $9 10/16/2017 10/16/2022 Common 833 833 D
    Options to Purchase Common Stock $66 05/22/2019 05/22/2024 Common 833 833 D
    Warrants to Purchase Common Stock $60 12/07/2018 12/07/2022 Common 1,667 1,667 I By Stephen Forman Living Trust
    Explanation of Responses:
    1. Effective June 30, 2025, the reporting person was granted stock options to purchase an aggregate of 10,000 shares vesting in eight equal installments on the last day of each subsequent quarter until fully vested with vesting to start on September 30, 2025.
    2. Effective June 30, 2025 the reporting person was granted stock options in aggregate of 7,754 shares vesting immediately. The grant was in lieu of the quarterly cash compensation due to the reporting person under the Board Compensation Plan.
    /s/ Stephen Forman 07/08/2025
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
    Get the next $LIXT alert in real time by email

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