Amendment: SEC Form SCHEDULE 13D/A filed by Kymera Therapeutics Inc.

Item 3 is hereby amended and restated to read as follows: The Shares beneficially owned by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account were purchased with working capital (which may, at any given time, include margin loans made by brokerage firms in the ordinary course of business). The aggregate purchase price of the 2,798,795 Shares directly beneficially owned by BVF is approximately $63,667,671, including brokerage commissions. The aggregate purchase price of the 751,971 pre-funded warrants (the "Pre-Funded Warrants") owned by BVF is approximately $22,111,156. The aggregate purchase price of the 2,219,858 Shares directly beneficially owned by BVF2 is approximately $49,276,190, including brokerage commissions. The aggregate purchase price of the 532,598 Pre-Funded Warrants owned by BVF2 is approximately $15,877,547. The aggregate purchase price of the 353,412 Shares directly beneficially owned by Trading Fund OS is approximately $7,933,098, including brokerage commissions. The aggregate purchase price of the 52,733 Pre-Funded Warrants owned by Trading Fund OS is approximately $1,331,503. The aggregate purchase price of the 130,645 Shares held in the Partners Managed Account is approximately $2,921,245, including brokerage commissions. The aggregate purchase price of the 27,797 Pre-Funded Warrants held in the Partners Managed Account is approximately $960,907. Stock options held by Mr. Hrustanovic referencing 40,127 Shares, 20,063 Shares, 12,000 Shares, 12,000 Shares, 16,000 Shares and 16,000 Shares, 100,190 Shares of which Mr. Hrustanovic may be deemed to beneficially own, were awarded to him on August 20, 2020, June 16, 2021, June 15, 2022, June 15, 2023, June 18, 2024 and June 25, 2025, respectively, for no consideration in connection with his service on the Board. Pursuant to a certain agreement entered into between Partners and Mr. Hrustanovic, Mr. Hrustanovic is obligated to transfer the economic benefit, if any, received upon the sale of the Shares issuable upon exercise of the above referenced stock options to Partners.

Item 5(a) is hereby amended and restated to read as follows: The aggregate percentage of Shares reported owned by each person named herein is based upon a denominator that is the sum of: (i) 79,791,174 Shares outstanding as of December 11, 2025, which is the total number of Shares outstanding following the closing of the Issuer's underwritten public offering as reported in the Issuer's prospectus supplement on Form 424B5 filed with the Securities and Exchange Commission (the "SEC") on December 10, 2025, including 1,050,000 shares issued to the underwriters as reported in the Issuer's Current Report on Form 8-K filed with the SEC on December 10, 2025, and (ii) certain or all of the 1,365,099 Shares underlying the Pre-Funded Warrants held by the Reporting Persons and Partners Managed Account, as applicable. As of the date hereof, the Reporting Persons, together with the Partners Managed Account, hold an aggregate of 1,365,099 Pre-Funded Warrants, which are exercisable into an aggregate of 1,365,099 Shares. The Pre-Funded Warrants are exercisable at any time at an exercise price of $0.0001 per Share and do not expire. A holder of Pre-Funded Warrants will not be entitled to exercise any portion of any Pre-Funded Warrant held by them that, upon giving effect to such exercise, would cause the aggregate number of Shares beneficially owned by such holder (together with their attribution affiliates) to exceed 9.99% of the number of Shares that would be outstanding immediately after giving effect to the exercise (the "Warrants Blocker"). As of the date hereof, the Warrants Blocker does not limit the exercise of any of the Pre-Funded Warrants held by the Reporting Persons and the Partners Managed Account. In addition, if the exercise of a Pre-Funded Warrant would result in a holder of Pre-Funded Warrants (together with its attribution affiliates) acquiring beneficial ownership of Shares (together with all other equity owned by such holder at such time) equal to or in excess of the notification threshold (the "HSR Threshold") applicable to the holder under the Hart-Scott-Rodino Act (the "HSR Act") as of the date of delivery of the applicable exercise notice, and no exemption to filing a notice and report form under the HSR Act is applicable, then only such portion of the Pre-Funded Warrants held by such holder, which when exercised does not exceed the HSR Threshold, shall be exercisable and the applicable exercise notice shall be deemed to relate only to such portion of the Pre-Funded Warrants, and the remaining portion of the Pre-Funded Warrants in excess of the HSR Threshold shall not be exercisable until the expiration or early termination of the applicable waiting period under the HSR Act or receipt of applicable approval. As of the date hereof, (i) BVF beneficially owned 3,550,766 Shares, including 751,971 Shares underlying the Pre-Funded Warrants held by it, representing percentage ownership of approximately 4.4% of the Shares outstanding, (ii) BVF2 beneficially owned 2,752,456 Shares, including 532,598 Shares underlying the Pre-Funded Warrants held by it, representing percentage ownership of approximately 3.4% of the Shares outstanding, (iii) Trading Fund OS beneficially owned 406,145 Shares, including 52,733 Shares underlying the Pre-Funded Warrants held by it, representing percentage ownership of less than 1% of the Shares outstanding, and (iv) 158,442 Shares were held in the Partners Managed Account, including 27,797 Shares underlying the Pre-Funded Warrants held by it, representing percentage ownership of less than 1% of the Shares outstanding. BVF GP, as the general partner of BVF, may be deemed to beneficially own the 3,550,766 Shares beneficially owned by BVF, representing percentage ownership of approximately 4.4% of the Shares outstanding. BVF2 GP, as the general partner of BVF2, may be deemed to beneficially own the 2,752,456 Shares beneficially owned by BVF2, representing percentage ownership of approximately 3.4% of the Shares outstanding. Partners OS, as the general partner of Trading Fund OS, may be deemed to beneficially own the 406,145 Shares beneficially owned by Trading Fund OS, representing percentage ownership of less than 1% of the Shares outstanding. BVF GPH, as the sole member of each of BVF GP and BVF2 GP, may be deemed to beneficially own the 6,303,222 Shares beneficially owned in the aggregate by BVF and BVF2, representing percentage ownership of approximately 7.8% of the Shares outstanding. Partners, as the investment manager of BVF, BVF2 and Trading Fund OS, and the sole member of Partners OS, may be deemed to beneficially own the 6,867,809 Shares beneficially owned in the aggregate by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account, representing approximately 8.5% of the Shares outstanding. BVF Inc., as the general partner of Partners, may be deemed to beneficially own the 6,867,809 Shares beneficially owned by Partners, representing percentage ownership of approximately 8.5% of the Shares outstanding. Mr. Lampert, as a director and officer of BVF Inc., may be deemed to beneficially own the 6,867,809 Shares beneficially owned by BVF Inc., representing percentage ownership of approximately 8.5% of the Shares outstanding. As of the date hereof, Mr. Hrustanovic beneficially owned 100,190 Shares underlying certain stock options which have vested or will vest within 60 days hereof, excluding 16,000 Shares underlying certain stock options which have not vested and will not vest within 60 days hereof, representing percentage ownership of less than 1% of the Shares outstanding. The filing of this Schedule 13D shall not be deemed an admission that the Reporting Persons are, for purposes of Section 13(d) of the Exchange Act, the beneficial owners of any securities of the Issuer he or it does not directly own. Each of the Reporting Persons specifically disclaims beneficial ownership of the securities reported herein that he or it does not directly own.

Item 5(c) is hereby amended and restated to read as follows: The Reporting Persons have not entered into any transactions in the securities of the Issuer during the past 60 days.

Item 6 is hereby amended to add the following: Stock options referencing 16,000 Shares were awarded to Mr. Hrustanovic on June 18, 2024 for no consideration in connection with his service on the Board. Such stock options have vested in full as of the date hereof. Stock options referencing 16,000 Shares were awarded to Mr. Hrustanovic on June 25, 2025 for no consideration in connection with his service on the Board. Such stock options shall vest in full upon the earlier to occur of (i) June 25, 2026 and (ii) the date of the next annual meeting of the Issuer's stockholders. Pursuant to a certain agreement entered into between Partners and Mr. Hrustanovic, Mr. Hrustanovic is obligated to transfer the economic benefit, if any, received upon the sale of the Shares issuable upon exercise of the above referenced stock options to Partners.